報告題目🦂🚴🏿‍♂️：3-D Bio-printing, Stem Cells and Vascular Bioengineering

報 告 人👳🏼‍♀️：戴國豪 Associate Professor, Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute

報告時間🦹🏿‍♀️：7月13日 13:00

報告地點：閔行校區生物藥學樓2-116

聯 系  人：韓悅 This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Blood vessels play an increasingly important role in most human tissue and organ systems. Importantly, vascular niche was found to be a key element of many stem cell environments such as neural stem cells and cancer stem cells. Vascular cells not only form conduits to deliver nutrient and oxygen, but also provide instructive signals to control stem cell self-renewal and differentiation, therefore, is critical for tissue regeneration.  In this talk, he will present several projects in our Vascular Bioengineering Laboratory in the integration of 3-D Bio-printing, Stem Cells and Vascular Bioengineering for tissue regeneration.

1) 3D printing offers great power and flexibility to allow on-demand control of material configurations thus has great potential in tissue engineering applications, but its translation into creation of “live tissues” remains a significant challenge. In addition, maintaining the viability of thick tissue construct for tissue growth and maturation after the printing is challenging due to lack of vascular perfusion. The bioprinted vascular network has a great potential in engineering vascularized thick tissues and vascular niches. It can also serve as a unique experimental tool for investigating fundamental vascular biology under 3D dynamic conditions.

2) Pluripotent stem cells derived vascular endothelial cells (ECs) have enormous potential to be used in a variety of therapeutic areas such as tissue engineering of vascular grafts and re-vascularization of ischemic tissues. It is also much desired to obtain homogeneous culture of functional arterial or venous ECs for specific applications. Inspired by the findings of vascular development, we hypothesize that stem cell derived Flk1+Nrp1+ cells serve as arterial EC progenitors. We think that this subset cell population is predisposed to arterial differentiation and can be selected to guide arterial differentiation in combination with environmental cues.  My lab is currently developing methods to engineer optimal in vitro environments that guide stem cells into arterial and venous cell fate and compare their functional consequences in tissue engineering applications.  In addition, we are studying the role of venous-specific transcription factor COUP-TFII in the controlling of the arterial and venous cell fate as well as determining their functions in the adult vessel and vascular disease process.

個人簡介🫱🏼：

戴國豪（Guohao Dai）倫斯勒理工EON4生物醫學工程EON4副教授👨🏼‍🎨。從事心血管生物力學、力學生物學🌖、血管生物學和組織工程研究15年，在整合生物學前沿技術包括最新的三維打印和幹細胞技術發展和應用方面有很高的造詣🚴🏼，師從美國工程院院士、麻省理工EON4Roger Kamm教授和美國科EON4院士、美國醫學科EON4院士🍫、哈佛醫EON4病理系主任Michael Gimbrone教授。研究成果發表在Nature、PNAS、JCI、Cir Res、Biomaterials等國際著名期刊，被引用次數達1666👩🏽‍🌾🧑🏽‍🦲，在國際學術會議和學術機構作邀請報告20余次👩🏼，並獲得美國青年科學家之中最具競爭力的獎項🧝🏻‍♀️，包括美國心臟協會科學家發展獎🙆、美國國家科學基金會早期職業獎（NSF Career Award），美國生物醫學工程學會學術之星獎（Rising Star Award）。他還獲得了美國倫斯勒理工EON4院長的教授早期職業獎♿，成為該校今年唯一一位獲得此榮譽的教授🍟。