報告題目： Development and regeneration of the epidermis and its appendages: insights from mouse genetics

報  告 人：Professor Sarah E. Millar

School of Medicine, University of Pennsylvania

報告時間🎍💪🏿：6月17日  10:00-11:00

報告地點🔵：閔行校區生物藥學樓1-105會議室

聯  系 人：馬鋼  021-34207232

報告人介紹：Professor Sarah E Millar is tenure Professor and Chair of the Developmental, Stem Cell and Regenerative Biology Program of the Cell and Developmental Biology graduate group at Penn. Meanwhile, she was appointed Albert M. Kligman Endowed Professor of Dermatology and Vice Chair for Research, Department of Dermatology, University of Pennsylvania School of Medicine. She is a permanent member of the NIH ACTS study section and is an Editorial Board member for the journals Developmental Cell and Experimental Dermatology. Her research focuses on understanding molecular mechanisms controlling development, patterning, stem cell function and regeneration in ectodermal appendage organs including hair follicles, mammary glands, taste papillae and teeth.

Selected Publications👩🏿‍🎤：

Andl, T., Reddy S. T., Gaddapara, T. & Millar, S. E. : WNT signals are required for the initiation of hair follicle development. Developmental Cell 2: 643-653, 2002.

Chu, E. Y., Hens, J., Andl, T., Kairo, A., Yamaguchi, T. P., Brisken, C., Glick, A., Wysolmerski, J. J., & Millar, S. E. : Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 131: 4819-4829, 2004.

Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C, D., Seykora, J. T., Hannon, G. J., Millar, S. E.: The miRNA processing enzyme Dicer is essential for the morphogenesis and maintenance of hair follicles. Current Biology 6: 1041-9, 2006.

Liu, F., Thirumangalathu, S., Gallant, N. M., Yang, S. H., Stoick-Cooper, C. L., Reddy, S. T., Andl, T., Taketo, M. M., Dlugosz, A. A., Moon, R. T., Barlow, L. A., Millar, S. E.: Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet. 39: 106-12, 2007.

Zhang, Y., Andl, T., Yang, S.H., Teta, M., Liu, F., Seykora, J.T., Tobias, J.W., Piccolo, S., Schmidt-Ullrich, R., Nagy, A., Taketo, M.M., Dlugosz, A.A., Millar, S.E.:Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development 135: 2161-72, June 2008 Notes: Highlighted paper. Epub 2008 May 14.

Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek P, Scheidereit C, Millar SE*, Schmidt-Ullrich R*. [*Joint last and corresponding authors.]: Reciprocal requirements for Eda/Edar/NF-kappa B and Wnt/b-catenin signaling pathways in hair follicle induction. Developmental Cell 17, 49-61 2009.

Liu F, Dangaria S, Andl T, Zhang Y, Wright A C, Damek-Poprawa M, Piccolo S, Nagy A, Taketo M M, Diekwisch T G H, Akintoye S O, Millar S E: beta-Catenin initiates tooth neogenesis in adult rodent incisors. Journal of Dental Research 89(9): 909-14, Sep 2010.

LeBoeuf Matthew, Terrell Anne, Trivedi Sohum, Sinha Satrajit, Epstein Jonathan A, Olson Eric N, Morrisey Edward E, Millar Sarah E: Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells.Developmental Cell 19(6): 807-18, Dec 2010.

Teta Monica, Choi Yeon Sook, Okegbe Tishina, Wong Gabrielle, Tam Oliver H, Chong Mark M W, Seykora John T, Nagy Andras, Littman Dan R, Andl Thomas, Millar Sarah E: Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development (Cambridge, England) 139(8): 1405-16, Apr 2012.

Choi Yeon Sook, Zhang Yuhang, Xu Mingang, Yang Yongguang, Ito Mayumi, Peng Tien, Cui Zheng, Nagy Andras, Hadjantonakis Anna-Katerina, Lang Richard A, Cotsarelis George, Andl Thomas, Morrisey Edward E, Millar Sarah E: Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell stem cell 13(6): 720-33, Dec 2013