報告題目：Biotransformation of Aromatic Rings to Cyclohexadiene-diols

報 告  人😏👀：Dr. Simon Lewis      University of Bath

報告時間🫱🏿✔️：11月12日下午14:00

報告地點：閔行校區生物藥學樓2-116

聯 系  人：林雙君   This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

報告人介紹：We are interested in using bacteria to carry out dihydroxylation of aromatic rings—a process that is very difficult by conventional chemical means. Of the strains identified or engineered to date, the majority metabolise substituted arenes to dihydrodiols with the ortho,meta-substitution pattern.  Much rarer is the formation of ipso,ortho-substituted dihydrodiols.  We are exploiting the microbial ipso,ortho-dihydroxylation of benzoic acid, producing a versatile chiral building block for synthesis.