報告題目：面向化學品和材料的微生物代謝工程

Microbial metabolic engineering for chemicals and materials

報 告  人：李相燁 博士（Sang Yup Lee）

韓國科學技術院（KAIST）特聘教授

韓國國家科學與工程院院士

美國工程院外籍院士

報告時間：9月18號（星期四） 10：00

報告地點：閔行校區生物藥學樓樹華多功能廳

聯 系  人：錢誌剛 This e-mail address is being protected from spambots. You need JavaScript enabled to view it. 13817451799

報告摘要：Microbial metabolic engineering for chemicals and materials

Sang Yup Lee

Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, Republic of Korea

Due to our increasing awareness of climate change and environmental problems in addition to the limited nature of fossil resources, there has recently been much interest in developing sustainable system for the production of chemicals, fuels, and materials from renewable resources. Metabolic engineering has been successfully practices over two decades for the enhanced production of chemicals and pharmaceuticals. More recent advances in systems biology, synthetic biology and evolutionary engineering are allowing metabolic engineering to be performed at systems level. In this lecture, systems metabolic engineering strategies that integrate systems biological and synthetic biological approaches with metabolic engineering will be described. Several examples of producing chemicals, fuels and materials will be described in the context of systems metabolic engineering. First, amino acids will be used as example products of systems metabolic engineering. How cellular networks are engineered to overcome negative regulatory circuits, reinforcing the metabolic fluxes towards the desired product, and how fermentation is coupled during the strain development will be described. Also, development of microbial strains for the production of other chemicals and materials of industrial importance will be showcased. [Our work has been supported by the Technology Development Program to Solve Climate Changes from the Ministry of Education, Science and Technology.]

Recent references

1. Lee, J.W. et al., Nature Chemical Biology 2012, 8, 536 – 546

2. Na, D. et al., Nature Biotechnology, 2013, 31, 170 - 174

3. Choi, Y.J. and Lee, S.Y., Nature, 2013, 502, 571 – 574

4. Kim, B. et al., Biotechnol. J., 2014, 9, 621-629

5. Choi, S. et al., Metabol. Eng., 2013, 20, 73-83

more references from http://mbel.kaist.ac.kr/lab/publication/interJournal/interJournal.htm