報告題目：Microbial biosynthesis of terminal alkenes and alkynes

報  告 人💱：張文君 博士，University of California, Berkeley

報告時間：9月18日（星期四）14⚫️：00

報告地點♦️：徐匯校區哲生館1樓會議室

聯  系 人：林雙君 This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

報告摘要：

Terminal alkene and alkyne are readily derivatized functionalities commonly used in chemical synthesis and bioorthogonal reactions. These functionalities are also found in various natural products, but the biosynthetic mechanisms often remain elusive.  We recently identified and characterized two biosynthetic pathways in microbes leading to the generation of terminal alkene and alkyne respectively.  Particularly, a novel non-heme iron dependent decarboxylase/desaturase was revealed to convert fatty acids to terminal olefins; and fatty terminal olefins could be transformed into terminal alkynes through an unprecedented thio-templated pathway.