報告題目🌛：Probing the diversified bacterial lipid metabolism, an attractive anti-bacterial drug target

報  告 人：馮友軍 教授

浙江大學醫EON4

報告時間👨‍🎓：5月19日（星期一）9:30-11:30

報告地點：生物藥學樓3號樓405

聯  系 人：何亞文👸，34207941,   This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

研究成果

申請人主要通過病毒/細菌遺傳學、分子生物學、生物化學、生物信息學、化學生物學、比較功能基因組學🏋🏿‍♂️、結構生物學、分子免疫學和細胞/實驗動物的感染生物學等多種研究手段研究病原菌的脂代謝調控以及其感染機製。博士期間的主要研究方向集中在高致病性病原體如豬鏈球菌(Streptococcus suis, S. suis)和禽流感病毒 (Avian influenza virus H5N1 & H7N9) 的分子致病機製和病原結構上🧙🏿‍♀️，現已取得的研究成果發表在PLoS Medicine, Journal of Bacteriology, The Journal of Infectious Diseases, Journal of Clinical Microbiology, Journal of General Virology, Science等國際期刊上🙍🏿‍♂️。申請人在美國伊利諾伊大學的研究主要是以食源性病原菌(如大腸桿菌和霍亂弧菌等)為研究材料，從事細菌脂肪酸及衍生物的代謝調控機理的研究，所取得的系列研究成果已經在本領域著名刊物如Molecular Microbiology和Journal of Bacteriology發表十余篇研究論文。迄今為止，申請人以第一作者/通訊作者身份在本領域的知名國際學術期刊(包括PLoS Medicine, Molecular Microbiology, Journal of Bacteriology, The Journal of Biological Chemistry, The Journal of Infectious Diseases, Emerging Infectious Diseases等)上發表了50余篇研究論文，取得了多項重要研究成果。其中第一作者/通訊作者文章共30余篇🎟，他引次數為366次。申請人與國內外多家科研單位也建立了廣泛👊🏻、深入的學術聯系🦹🏿，目前擔任包括Virulence (IF: 2.787)在內多家學術刊物的雜誌編委和數個國際刊物的審稿人。

研究領域

1.1 致病性病原細菌的脂肪酸代謝調控機製研究

1.2 病原細菌的維生素H（生物素）合成與利用的調控機理

1.3 豬鏈球菌（Streptococcus suis）的致病機理研究

代表性文章

1. Youjun Feng, John E. Cronan, PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis, Research in Microbiology, 2014, May 6, Epub ahead of print

2. Youjun Feng*, et al. Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases? Virulence, 2014 Mar 25; 5(4).

3. Dan Hu, …… Youjun Feng*, Changjun Wang*, The β-galactosidase (BgaC) of the zoonotic pathogen Streptococcus suis is an atypical surface-exposed protein without the involvement of bacterial virulence, Scientific Reports, 2014 Feb 21;4:4140

4. Yang W, Lian J, Youjun Feng, et al. Genome-wide miRNA profiling of Aflatoxin B1-induced hepatic injury using deep sequencing. Toxicology Letter, 2014

5. Youjun Feng, et al. A Francisella virulence factor catalyzes an essential reaction of biotin synthesis. Molecular Microbiology, 2014, 91(2): 300-314.

6. Yi Fang, Youjun Feng, et al. Aflatoxin B1 negatively regulates Wnt/β-catenin signaling pathway through activating miR-33a, 2013, PLoS One, 8（8）: e73004.

7. Rongzhi Wang, Shuangshuang Xiang, Youjun Feng, et al. Engineering production of functional scFv antibody in E. coli by co-expressing the molecule chaperone Skp, 2013, Front. Cell. Infect. Microbiol. doi: 10.3389/fcimb.2013.00072

8. Rajesh Kumar Biswas, Debashis Dutta, Ashutosh Tripathi, Youjun Feng, et al. Identification and characterization of Rv0494: a fatty acid responsive protein of the GntR/ FadR family from Mycobacterium tuberculosis, 2013, Microbiology, 159（5）:913-923

9. Youjun Feng, Huimin Zhang, John E. Cronan, Profligate biotin synthesis in α-proteobacteria – A developing or degenerating regulatory system? Molecular Microbiology, 2013, 88（1）:77-92