報告題目✍🏽：Novel Regulation and Function of the Tumor Suppressor PTEN

報 告  人🧝🏻：Dr. Xuejun Jiang， Professor， Memorial Sloan-Kettering Cancer Center

報告時間：12月3日 上午10:30-12:00

報告地點：閔行校區生物藥學樓2-116會議室

聯 系  人👷🏻‍♂️：馬小京   This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

簡介：

Xuejun Jiang教授本科畢業於復旦大學生物化學專業，於1999年獲美國Univ. of Texas Southwestern Medical Center藥學系博士學位🤹🏽‍♀️。現任美國Memorial Sloan-Kettering Cancer Center及Cornell University Weill Medical College教授🎅🏿。主要研究方向為: 1. 程序性細胞死亡的分子機製; 2. 腫瘤抑製物PTEN的調控。在Science, Cell, Molecular Cell，Nat Struct Mol Biol.等國際重要期刊發表論文多篇。

主要論文🚣🏼‍♂️：

Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC, Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway. Science. 2003 Jan 10; 299(5604):223-6.

Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 2007 Jan 12;128(1):129-39.

Ganley IG, Wong PM, Gammoh N, Jiang X. Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell. 2011 Jun 24;42(6):731-43. doi: 10.1016/j.molcel.2011.04.024.

Feldman T, Kabaleeswaran V, Jang SB, Antczak C, Djaballah H, Wu H, Jiang X. A class of allosteric caspase inhibitors identified by high-throughput screening. Mol Cell. 2012 Aug 24;47(4):585-95. doi: 10.1016/j.molcel.2012.06.007. Epub 2012 Jul 12.

Gammoh N, Florey O, Overholtzer M, Jiang X. Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy. Nat Struct Mol Biol. 2013 Feb;20(2):144-9. doi: 10.1038/nsmb.2475. Epub 2012 Dec 23.