報告題目: RNA Binding Proteins in Neurodegeneration

報 告  人: 吳瑛 教授

報告時間: 11月1日，上午10:30

報告地點: 生物藥學樓3-403

聯 系  人:曹成喜    34205820     This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

報告人簡介:

吳瑛，博士🍖，高級研究顧問。

1980-1986 上海醫科大學👨‍🦲，醫學學士

1986-1991 美國斯坦福大學，博士

1991-1994 美國哈佛大學，博士後

1994-2003 美國華盛頓大學醫EON4，助理教授👩‍❤️‍👩、副教授

2003-2005 美國Vanderbilt大學，教授

2005-　美國西北大學醫EON4，Lurie 癌症中心，Charles Luis Mix 教授

主要研究參與神經發育和神經推行性病變的基因調控的分子機製👍。具體研究內容分為兩個方面:1）RNA調控；2）細胞遷移的分子機製。

Selected Publications🎛👷🏽：

1.　Li Y, Ray P, Rao EJ, Shi C, Guo W, Chen X, Woodruff EA, Fushimi K, Wu JY*. A Drosophila model for TDP-43 proteinopathy. Proc. Natl. Acad. Sci. USA. 2010; 107:3169-74.

2.　Guo W, Li JT, Pan X, Wei L, Wu JY*. Candidate Mycobacterium tuberculosis genes targeted by human microRNAs. Protein Cell. 2010; 1(5): 419-21.

3.　Guo W, Chen Y, Zhou X, Kar A, Ray P, Chen X, Rao EJ, Yang M, Ye H, Zhu L, Liu J, Xu M, Yang Y, Wang C, Zhang D, Bigio EH, Mesulam M, Shen Y, Xu Q, Fushimi K, Wu JY*. An ALS-associated mutation in the TDP-43 gene enhances protein aggregation, fibril formation and neurotoxicity. Nat Struct Mol Biol. 2011 Jun;18(7):822-30.

4.　Chen Y, Yang M, Deng J, Chen X, Ye Y, Zhu L, Liu J, Ye H, Shen Y, Li Y, Rao EJ, Fushimi K, Zhou X, Bigio EH, Mesulam M, Xu Q, Wu JY*. Expression of human FUS protein in drosophila leads to progressive neurodegeneration. Protein Cell. 2011 Jun;2(6):477-86.

5.　Zhu L, Millen L, Mendoza JL, Thomas PJ. A unique redox-sensing sensor-II motif in torsinA plays a critical role in nucleotide and partner binding. J Biol Chem. 2010; 285:37271-80.

6.　Ye H, Zhao T, Tan YL, Liu J, Pallen CJ, Xiao ZC. Receptor-like protein-tyrosine phosphatase {alpha} enhances cell surface expression of neural adhesion molecule NB-3. J Biol Chem. 2011 Jul; 286(29):26071-80.

7.　Xu Y, Ye H, Shen Y, Xu Q, Zhu L, Liu J, Wu JY*. Dscam mutation leads to hydrocephalus and decreased motor function. Protein Cell. 2011 Aug; 2(8):647-55.

8.　Zhu L, Liu J, Wu JY. Impaired post-transcriptional regulation in Alzheimer’s disease. Prog Biochem Biophys. 2012; 39:703-8. (invited review)

9.  Liu K, Liu Y, Mo W, Qiu R, Wang X, Wu JY and He R*. MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1. Nucleic Acids Res. 2011; 39(7): 2869-79.

10.  Qiu R, Liu K, Liu Y, Mo W, Flynt AS, Patton JG, Kar A, Wu JY and He R*. The role of miR-124a in early development of the Xenopus eye. Mech Dev. 2009; 126(10): 804-16.

11.  Qiu R, Liu Y, Wu JY, Liu K, Mo W and He R*. Misexpression of miR-196a induces eye anomaly in Xenous laevis. Brain Research Bulletin. 2009; 76: 26-31.