報告題目: Chromatin remodeling and histone modification: their roles in DNA repair
報  告  人: Gong Feng
Assistant Professor, tenure-track
Department of Biochemistry and Molecular Biology
University of Miami Miller School of Medicine, Miami, FL
Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
報告時間: 2011年11月29日（星期二）下午14:00時
報告地點: EON体育4平台3-105會議室
組織單位: EON体育4平台
報告基本信息：

Positions and Employment
1995-1998    Research Assistant under Prof. HY Song, Shanghai Institute of Plant physiology, Shanghai Institutes of Biological Sciences (SIBS), the Chinese Academy of Sciences, Shanghai, China
1998-2001    Postdoctoral Research Fellow, Mentor: Dr. Charles Yanofsky, Department of Biological Sciences, Stanford University, Palo Alto, CA
2001-2003    Research Associate, Dr. Charles Yanofsky laboratory , Department of Biological Sciences, Stanford University, Palo Alto, CA
2003-2007       Research Assistant Professor, School of Molecular Biosciences, Washington State University, Pullman, WA
2007-present    Assistant Professor, tenure-track, Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL

Honors
President Fellowship, SIPP, the Chinese Academy of Sciences (1996)
Di-Ao Scholar Award, the Chinese Academy of Sciences (1997-1998)
Special Award for Excellence in Teaching, Washington State University (2005)
Guest Editor, the Elsevier Journal Methods 2008-2009
Young Investigator Award from the Concern Foundation for Cancer Research (2008, 2009)

A.     Selected Peer-reviewed Publications (Selected from 25 peer-reviewed publications)

Most relevant to the current application
1.      F. Gong, Y Kwon and M.J. Smerdon. 2005. Nucleotide excision repair in chromatin and the right of entry. DNA Repair 4(8): 884-96. PMID: 15961354
2.      F. Gong, D. Fahy and M. Smerdon. 2006. Rad4–Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair. Nature Structural & Molecular Biology 13: 902 – 907. PMID: 17013386
3.         F. Gong, D. Fahy, H. Liu, W. Wang and M. Smerdon. 2008. Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage. Cell Cycle 7(8): 1069-1076. PMID: 18414052
4.      L. Zhang, Q. Zhang, K. Jones, M. Patel and F. Gong. 2009. The chromatin remodeling factor BRG1 stimulates nucleotide excision repair by facilitating recruitment of XPC to sites of DNA damage. Cell Cycle. 8(23): 3953 – 3959. PMID: 19901545
5.      L. Zhang L, J.J. Hu and F. Gong. 2011. MG132 inhibition of proteasome blocks high-dose UV irradiation-induced apoptosis. Cell Cycle. 10(20): 3515 - 3518. PMID: 22031102

Additional 10 recent publications (in chronological order)
1.      F. Gong, K. Ito, Y. Nakamura and C. Yanofsky. 2001. The mechanism of tryptophan induction of tryptophanase operon expression: tryptophan inhibits release factor 2 mediated cleavage of TnaC-peptidyl-tRNAPro. Proc. Natl. Acad. Sci. USA, 98(16): 8997-9001. PMID: 11470925
2.      F. Gong and C. Yanofsky. 2001. Reproducing tna operon regulation in vitro in an S-30 system: tryptophan induction inhibits cleavage of TnaC-tRNA. J. Biol. Chem. 276(3): 1974-83. PMID: 11050101
3.      F. Gong and C. Yanofsky. 2002. Analysis of tryptophanase operon expression in vitro: accumulation of TnaC-peptidyl-tRNA in S-30 extracts depleted of release factor 2 prevents Rho-factor action, simulating induction. J. Biol. Chem, 277(19): 17095-100. PMID: 11880383
4.      F. Gong and C. Yanofsky. 2002. Instruction of translating ribosome by nascent peptide. Science, 297: 1864-7 (covered by a perspective article in Science). PMID: 12228716
5.      F. Gong and C. Yanofsky. 2003. A transcriptional pause synchronizes translation with transcription in the tryptophanase operon leader region. J Bacteriol. 185(21): 6472-6. PMID: 14563884
6.      M. Gong, F. Gong and C. Yanofsky 2005. Overexpression of tnaC of E. coli inhibits growth by depleting tRNA2Pro availability. J Bacteriol. 188(5): 1892-8. PMID: 16484200
7.      R. Nag, F. Gong, D. Fahy and M. Smerdon. 2008. A single amino acid change in histone H4 enhances UV survival and DNA repair in yeast. Nucleic Acids Res. 36: 3857-3866. PMID: 18508805
8.      L. Zhang, K. Jones and F. Gong. 2009. The Molecular Basis of chromatin dynamics during Nucleotide Excision Repair. Biochemistry and Cell Biology 87(1):265-72. PMID: 19234540
9.      L. Zhang, K. Jones, M. Smerdon and F. Gong. 2009. Assays for chromatin remodeling during nucleotide excision repair in Saccharomyces cerevisiae. Methods 48(1):19-22. PMID: 19336254
10.  K. Jones, L. Zhang, Seldeen KL, F. Gong. 2010. Detection of bulky DNA lesions: DDB2 at the interface of chromatin and DNA repair in eukaryotes. IUBMB Life. 62(11):803-11. PMID: 21117171