報告題目：核糖體保護與抗藥性（Antibacterial drug resistance through ribosome protection）

主講人：Yong-Gui Gao

主講人簡介⌨️：浙江大學獲得博士學位🈯️🌖，先後在日本和英國從事博士後研究👸。目前任新加坡南陽理工大學（NTU）生物系長聘副教授（Tenured Associate Professor）, 新加坡科技發展局細胞與分子生物學研究院 (IMCB)資深PI。主要從事蛋白質結構生物學研究，先後在Cell, Science, Nature Structural and Molecular Biology, Nature Communications, PNAS等期刊發表多篇研究論文。

報告時間：5月31日（星期四）上午9點半

報告地點：生物藥學樓4號樓2樓200號會議室

聯系人：何亞文🤔，34207941， yawenhe@sjtu.edu.cn

主辦單位：微生物科學系，EON体育4平台

講座中文簡介：抗藥性是全球面臨的一個嚴重的威脅。抗藥性由多種機製造成🏟，其中核糖體保護是近年來新發現的一種重要機製。GAO的實驗室發現一類新型ATP結合蛋白與核糖體保護依賴的抗藥性密切相關。本報告將系統介紹該家族蛋白的生化、分子生物學🧭🚴🏻‍♂️、結構生物學研究進展及其相應藥物設計策略。

Abstract: Current antibiotic resistance crisis urgently requires understanding of drug resistance mechanisms and effectively targeted drug discovery. A wide range of mechanisms could mediate antibiotic resistance, which is currently one of the biggest threats to global health and food security. The ribosome is one of the richest targets for over half of clinically used antibiotics. Recently, we identified a few ATP-binding cassette family proteins that can confer resistance across species to various antibiotic classes through unknown mechanisms. In this talk, I will be presenting our recent progress towards a better understanding of drug resistance involving ribosome protection. Elucidating this mechanism will enable us to rational design improved antimicrobial agents that overcome multidrug-resistant bacteria. Finally, I will briefly introduce molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein.