戴少波

長聘教軌副教授

  • 電話:+86-021
  • 郵箱:sdai@sjtu.edu.cn
  • 地址:上海市閔行區東川路800號EON体育4閔行校區系統生物醫學研究所C402室
  • 實驗室網址☎:https://www.x-mol.com/groups/Dai_Shaobo
  • PI🍪👨🏿‍🚒,博士生導師🔪。闡述代謝關鍵酶的功能和催化機理🤞🏻,結合X射線晶體衍👧🏽、酶動力學👮‍♂️、光譜和化學生物學等對多種酶進行研究,包括硫胺素焦磷酸依賴酶和蛋白質甲基化酶,發表論文包括Nature, Nature Communications等。歡迎對酶學,蛋白質工程和化學生物學感興趣的同學加入🌤。

學術經歷

  • 2005–2009 西北大學💋,生命科學與技術(基地班),學士
  • 2009–2012 西北大學,生物化學與分子生物學🧑🏽‍🍳,碩士
  • 2013–2017 哥廷根大學/馬普所生物物理化學研究所(德國),分子酶學,博士
  • 2017–2021 MD安德森癌症中心(美國),博士後
  • 2021至今 EON体育4,EON体育4平台⚆👩🏼‍🔧,長聘教軌副教授

研究方向

生物途徑關鍵酶的抑製劑研究

生物途徑關鍵酶的抑製劑研究

蛋白質工程與酶進化

蛋白質工程與酶進化

化學法和酶法合成天然產物

化學法和酶法合成天然產物

酶催化過程的結構🚇、催化機理和中間體

酶催化過程的結構、催化機理和中間體

代表論著

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    Dai, S., Funk, L.-M., von Pappenheim, F. R., Sautner, V., Paulikat, M., Schröder, B., Uranga, J., Mata, R. A. & Tittmann, K. (2019) Low-barrier hydrogen bonds in enzyme cooperativity. Nature, 573(7775) 609-613. Recommended in F1000Prime.

    •  

    Wilkinson A.W.*, Diep J.*, Dai S.*, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, Cowan T, Elias JE, Nagamine CM, Spudich JA, Cheng X, Carette JE, Gozani O (2019) SETD3 is an actin histidine methyltransferase that prevents primary dystocia. (*co-first authors) Nature, 565(7739) 372-376. Recommended in F1000Prime.

    •  

    Zhihong Xiao, Jinyin Zha, Xu Yang, Tingting Huang, Shuxin Huang, Qi Liu, Xiaozheng Wang, Jie Zhong, Jianting Zheng, Rubing Liang, Zixin Deng, Jian Zhang*, Shuangjun Lin*, Shaobo Dai*. (2024) A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D. Nature Communications, 15(2128): 1-15.

    •  

    Zhiyong Liu, Chengliang Xiao, Shuangjun Lin, Kai Tittmann*, Shaobo Dai*. (2023) Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis. ACS Catalysis.

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    Xi-Wei Chen, Zhiyong Liu, Shaobo Dai*, Yi Zou*. (2024) Discovery, Characterization and Engineering of the Free l-Histidine C4-Prenyltransferase. Journal of the American Chemical Society. 2024, Aug 14. doi: 10.1021/jacs.4c08388.

  • •  

    Qinglong Shi, Xiu-Wen Kang, Zhiyong Liu, Pandaram Sakthivel, Hasil Aman, Rui Chang, Xiaoyu Yan, Yubin Pang, Shaobo Dai*, Bei Ding*, Juntao Ye*. (2023) Single-electron oxidation-initiated enantioselective hydrosulfonylation of olefins enabled by photoenzymatic catalysis. Journal of the American Chemical Society. 2024, 146(4): 2748-2756

    •  

    Dai S., Horton J.R., Woodcock C.B., Wilkinson A.W., Zhang X., Gozani O., Cheng X. (2019) Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nature Communications 10(1) 3541

    •  

    Dai S, Holt MV, Horton JR, Woodcock CB, Patel A, Zhang X, Young NL, Wilkinson AW, Cheng X. Characterization of SETD3 methyltransferase mediated protein methionine methylation. Journal of Biological Chemistry. 2020, 295, 10901-10910 (cover story).

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    Dai S, Horton JR, Wilkinson AW, Gozani O, Zhang X, Cheng X. An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation. Journal of Biological Chemistry. 2020, 295 (9), 2582-2589.

獲獎情況

  • 2019---美國晶體學會(American Crystallographic Association)RCSB PDB 最佳墻報獎
  • 2020---MD安德森癌症中心最佳論文獎
  • 2021---MD安德森癌症中心Ben F. Love fellowship in Innovative Cancer Therapies
  • 2022---上海市海外高層次引進人才
  • 2024---國家級青年人才
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