副研究員
天然產物是藥物的重要來源，本課題組聚焦於復雜活性天然產物（當前主要集中在聚酮和核苷類抗生素）的生物合成👬。綜合生物催化🤼♂️，結構生物學，酶工程，合成生物學等多學科技術手段，對復雜微生物天然產物的生物合成展開研究™️👨🏻🦽➡️，並揭示其中蘊含的新功能酶的催化機製；在了解生物合成途徑的基礎上嘗試對其進行改造以獲得結構改變活性更好的化合物結構，為發現和研製生物藥物先導化合物奠定物質基礎🤟🏽。
O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis. Zhao Y, Liu X, Xiao Z, Zhou J, Song X, Wang X, Hu L, Wang Y, Sun P, Wang W, He X, Lin S, Deng Z, Pan L, Jiang M. Nat Commun. 2023, 14(1):5372.
Importance of aspartic acid side chain carboxylate-arginine interaction in substrate selection of arginine 2,3-aminomutase BlsG. Luo X, Wang X, Zhang L, Du A, Deng Z , Jiang M*, He X*, Protein Sci. 2023, 32(3):e4584.
Unexpected Role of a short-chain dehydrogenase/reductase family protein in type II polyketide biosynthesis. Gao Y, Zhao Y, Zhou J, Yang M, Lin L, Wang W, Tao M, Deng Z, Jiang M, Angew Chem Int Ed Engl. 2022, 61(7): e202110445.
A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S. Wang X, Zhao Y, Gao Y, Luo X, Du A, Deng Z, Zabriskie TM, He X, Jiang M. Proc Natl Acad Sci U S A. 2021, 118(30): e2102318118.
Offloading role of a discrete thioesterase in type II polyketide biosynthesis. Hua K, Liu X, Zhao Y, Gao Y, Pan L, Zhang H, Deng Z, Jiang M. mBio. 2020, 11(5):e01334-20.
Heterologous Biosynthesis of Type II Polyketide Products Using E. coli. Liu X, Hua K, Liu D, Wu ZL, Wang Y, Zhang H, Deng Z, Pfeifer BA, Jiang M. ACS Chem Biol. 2020 May 15;15(5):1177-1183.
Liu X, Liu D, Xu M, Tao M, Bai L, Deng Z, Pfeifer BA, Jiang M. Reconstitution of kinamycin biosynthesis within the heterologous host streptomyces albus J1074, J Nat Prod., 2018, 81(1): 72~77.
Gao G, Liu X, Xu M, Wang Y, Zhang F, Xu L, Lv J, Long Q, Kang Q, Ou HY, Wang Y, Rohr J, Deng Z, Jiang M*, Lin S*, Tao M*. Formation of an angular aromatic polyketide from a linear anthrene precursor via oxidative rearrangement. Cell Chem Biol. 2017, 24(7):881-891.
科技部重點研發項目🤼，放線菌底盤與異源途徑適配性優化，2020-2024👩🏽💻。
EON体育4科技創新專項,聚酮類天然產物的生物合成機製研究，2016-2018。
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