黃顯清

副教授

  • 電話:
  • 郵箱:xqhuang66@sjtu.edu.cn, xqhuang66@126.com
  • 博士,副教授。主要從事假單胞菌抗生素合成的分子調控機製𓀒🧩、網絡🏇🏿、工程及應用研究💡。主持完成863課題1項🔫、國家自然基金3項。以第一或通訊作者在Mol Microbiol👧🏽、J Bacteriol等刊物上發表10多篇論文。參與的“申嗪黴素研製及應用”項目獲2007年上海科技進步一等獎🌖。

學術經歷

  • 2005年4月畢業於上海交大生命EON4生化與分子生物學專業4️⃣,獲理學博士學位🥵,同年留校工作,07年12月起擔任副教授👃🏼。

研究方向

3. 微生物源農藥及其它藥物、高附加值產物的應用及開發研...

  

2. 微生物初級與次級代謝的全局調控網絡、代謝工程及合成...

  

1. 假單胞菌抗生素合成的分子調控機製、網絡及代謝工程

  

代表論著

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    [1] Zheng Wang, Xianqing Huang *, Malik Jan, Deyu Kong, Wei Wang, Xuehong Zhang *. 2021. Lon protease downregulates phenazine-1-carboxamide biosynthesis by degrading the quorum sensing signal synthase PhzI and exhibits negative feedback regulation of Lon itself in Pseudomonas chlororaphis HT66. Molecular Microbiology. 2021,116:690–706. (* Co-corresponding authors)

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    [2] Zheng Wang, Xianqing Huang *, Yujie Liu, Guohuan Yang, Yang Liu, Xuehong Zhang. 2017. GacS/GacA activates pyoluteorin biosynthesis through Gac/Rsm-RsmE cascade and RsmA/RsmE-driven feedback loop in Pseudomonas protegens H78. Molecular Microbiology 105: 968-985. (*Corresponding author)

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    [3] Zheng Wang, Xianqing Huang *, Chenxi Nie, Tao Xiang, Xuehong Zhang*. 2022. The Lon protease negatively regulates pyoluteorin biosynthesis through the Gac/Rsm-RsmE cascade and directly degrades the transcriptional activator PltR in Pseudomonas protegens H78. Environmental Microbiology Reports. 2022 Mar 16. doi:10.1111/1758-2229.13057. Online ahead of print. (*Corresponding authors)

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    [4] Zheng Wang, Xianqing Huang *, Malik Jan, Deyu Kong, Jingwen Pan, Xuehong Zhang *. 2021. The global regulator Hfq exhibits far more extensive and intensive regulation than Crc in Pseudomonas protegens H78. Molecular Plant Pathology.  doi:10.1111/mpp.13070. (Co-corresponding authors)

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    [5] Lingyu Wu#, Zheng Wang#, Yejun Guan, Xianqing Huang *, Huimin Shi, Yujie Liu, Xuehong Zhang. 2020. The (p)ppGpp-mediated stringent response regulatory system globally inhibits primary metabolism and activates secondary metabolism in Pseudomonas Protegens H78. Applied Microbiology and Biotechnology 104: 3061-3079. (# Co-first authors; * Corresponding author)

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    [5] Yujie Liu, Huimin Shi, Zheng Wang, Xianqing Huang*, Xuehong Zhang. 2018. Pleiotropic control of antibiotic biosynthesis, flagellar operon expression, biofilm formation, and carbon source utilization by RpoN in Pseudomonas protegens H78. Applied Microbiology and Biotechnology 102: 9719-9730. (*Corresponding author)

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    [4] Huimin Shi, Xianqing Huang*, Zheng Wang, Yejun Guan, Xuehong Zhang. 2019. Improvement of pyoluteorin production in Pseudomonas protegens H78 through engineering its biosynthetic and regulatory pathways. Applied Microbiology and Biotechnology 103: 3465-3476. (*Corresponding author)

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    [6] Xue Wei #, Xianqing Huang #,*, Lulu Tang, Daqiang Wu, Yuquan Xu *. 2013. Global control of GacA in secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18. Journal of Bacteriology  195: 3387-3400.  (* Corresponding authors, #Co-first authors)

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    [7] Guohao Wang#, Xianqing Huang #,*, Sainan Li, Jiaofang Huang, Xue Wei, Yaqian Li, Yuquan Xu*. 2012. The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18. Journal of Bacteriology 194: 2443-2457.  (*Corresponding authors, #Co-first authors)

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