長聘教軌副教授
基於Aβ在阿爾茲海默症發病過程中可能扮演的重要角色，以及已報道的Aβ在神經細胞表面的天然受體LilrB2，開發阿爾茲海默症的早期診療藥物。
基於已解析的纖維結構🥐，通過設計可結合於纖維表面的小分子🈹，以達到抑製蛋白纖維化的目的♌️𓀜。設計出的抑製劑將在體外和細胞層面進行驗證，這些抑製劑的成功設計將有助於相關疾病的藥物研發🌐。
通過使用冷凍電鏡螺旋重構的方法解析與疾病相關的澱粉樣纖維（一種蛋白質聚集形式）的近原子分辨率結構，從而探究其形成纖維的分子機理，以及研究這些蛋白的纖維化在相關疾病發病過程中所扮演的角色。
Cheng, Y., Kreutzberger, M., Han, J., Egelman, E#., and Cao, Q#. Molecular architecture of the assembly of Bacillus spore coat protein GerQ revealed by cryo-EM. Nat Commun 15, 8091 (2024).
Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q#. Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM. Nat Commun 14, 7503 (2023).
Jiang, Y. X*., Cao, Q*., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., and Eisenberg, D. S., “Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43” Nature, 605:304–309 (2022)
Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., and Eisenberg, D.S., “Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores” Nature Structural & Molecular Biology, 28:724-730 (2021)
Cao, Q*., Boyer, D. R*., Sawaya, M. R., Ge, P., and Eisenberg, D.S., “Cryo-EM structures of four polymorphic TDP-43 amyloid cores.” Nature Structural & Molecular Biology, 26: 619-627 (2019)
Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., and Jiang, L., “Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.” Nature Chemistry, 10: 1213–1221 (2018)
Guenther, E. L*., Cao, Q*., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., and Eisenberg, D. S., “Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.” Nature Structural & Molecular Biology, 25: 463-471 (2018)
Cao, Q., Anderson, D.H., Liang, W., Chou, J., and Saelices, L., “The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.” The Journal of Biological Chemistry, 295, 14015-14024 (2020)
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