長聘教軌副教授
采用系統生物學的手段，通過比較基因組學、細胞代謝模型預測和生理學實驗，揭示不同酵母菌株抗逆機製和代謝多樣性的進化起源🔓。
基於代謝模型理性預測🫔，結合定量蛋白質組學、代謝流組學和代謝物組學🧜🏻🧑🏻💼，尋找工業菌株高產的代謝瓶頸與調控機製，在系統層次上重塑細胞內資源分配和代謝流調節💒🦼，達到工業菌株的系統改造和優化設計。
以酵母為模式生物，系統整合多組學數據，同時結合機器學習算法👷🏻，開發新一代多尺度細胞代謝模型，全面提升模型預測性能🌰👩🏭。
H Lu* (co-corresponding author), L Xiao, W Liao, X Yan, J Nielsen*. Cell factory design with advanced metabolic modelling empowered by artificial intelligence. Metabolic Engineering, 2024.07
Yuan L, Lu H* (co-corresponding author), Li F, Nielsen J and Kerkhoven* EJ. HGTphyloDetect: facilitating the identification and phylogenetic analysis of horizontal gene transfer. Briefings in Bioinformatics, 2023: 1–7.
Lu H, Kerkhoven EJ, Nielsen J. Multiscale models quantifying yeast physiology: towards a whole-cell model. Trends in Biotechnology, 2022, 40(3):291-305.
Lu H#, Li F#, Yuan L#, Domenzain I, Yu R, Wang H, Li G, Chen Y, Ji B, Kerkhoven EJ, Nielsen J*. Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection. Molecular Systems Biology, 2021(17):e10427.
Lu H#, Li F#, Sánchez BJ, Zhu Z, Li G, Domenzain I, Marcišauskas S, Anton PM, Lappa D, Lieven C, Beber ME, Sonnenschein N, Kerkhoven EJ, Nielsen J*. A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism. Nature Communications, 2019, 10 (1):1-13.
Lu H, Chen Y, Nielsen J, Kerkhoven EJ. Kinetic Models of Metabolism. Metabolic Engineering: Concepts and Applications, 2021 (13): 153-170. Book chapter.
Lu H, Liu X, Huang M*, Xia J, Chu J*, Zhuang Y, Zhang S, Noorman H. Integrated isotope-assisted metabolomics and (13)C metabolic flux analysis reveals metabolic flux redistribution for high glucoamylase production by Aspergillus niger. Microb Cell Fact, 2015(14):147.
Lu H, Cao W, Ouyang L, Xia J, Huang M* , Chu J*, Zhuang Y, Zhang S, Noorman H. Comprehensive reconstruction and in silico analysis of Aspergillus niger genome-scale metabolic network model that accounts for 1210 ORFs. Biotechnology and Bioengineering, 2017, 114(3):685-695.
Lu H#, Cao W#, Liu X, Sui Y, Ouyang L*, Xia J, Huang M, Zhuang Y, Zhang S, Noorman H, Chu J*. Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition. Sci Rep, 2018, 8(1):14404.
現授“細胞數字建模與應用”（研究生），2024秋季學期-
國家自然科學基金面上項目🚵🏿♂️，基於深度學習策略的酶約束代謝模型構建和分析方法研究👩🏼💼，主持👍🏼，2024.01.01 - 2027.12.31
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