副研究員
通過模擬生命極限條件下的環境條件，研究生命在極限條件下的物理變化🙎🏽♂️、結構變化💠、生理變化、代謝變化及生命過程的限製條件👮🏻，從而探索生命的邊界及地球生物圈的邊界，並為探索域外生命提供線索。
基於微生物群落宏基因組分析🦸🏿♂️，通過構建群落水平或種群水平的代謝網絡模型，在定性分析的基礎上定量計算原位環境變化時的微生物群落代謝網絡變化🤱🏽，並定量估算這種代謝變化帶來的環境影響📀◾️。
通過分離培養等手段從現代類早期地球環境中獲得現存的類早期極端微生物👩🏻🦯，通過研究該類極端微生物的形態、生理🤘🏿、代謝等特點及其環境適應機製👩🏻🍼，反推早期生命形態與早期地球的互作方式🦧，並推演生命-地球的演化歷程。
Zhao, W.,# Zhong, B.,# Zheng, L., Tan, P., Wang, Y., Leng, H., Souza, N., Liu, Z., Hong, L.,* & Xiao, X.,* Proteome-wide 3D structure prediction provides insights into the ancestral metabolism of ancient archaea and bacteria. Nature Communications 13, 7861 (2022). https://doi.org/10.1038/s41467-022-35523-8. （共同第一作者）
Liu, Y., Zhang, Z., Ji, M., Hu, A., Wang, J., Jing, H., Liu, K., Xiao, X.*, Zhao, W.*. Comparison of prokaryotes between Mount Everest and the Mariana Trench. Microbiome 10, 215 (2022). https://doi.org/10.1186/s40168-022-01403-y. （共同通訊作者）
Zhang, K.,# Zhao, W.,# Rodionov, D., Rubinstein, G., Nguyen, D., Tanwee, T., Crosby, J., Bing, R., Kelly, R., Adams, M., Zhang, Y., Genome-Scale Metabolic Model of Caldicellulosiruptor bescii Reveals Optimal Metabolic Engineering Strategies for Bio-based Chemical Production. mSystems. 6(3): e0135120. (2021) 10.1128/mSystems.01351-20. （共同第一作者）
Yang, Y., Zhao, W*., Xiao, X. The upper temperature limit of life under high hydrostatic pressure in the deep biosphere, Deep Sea Research Part I: Oceanographic Research Papers (2021) 176,103604, https://doi.org/10.1016/j.dsr.2021.103604. （通訊作者）
Zhao, W., Xiao, X. Life in multi-extreme environment: cross-stress response in Thermococcales. (2017). Kallmeyer, J. (Ed.), Life at Vents and Seeps. De Gruyter. pg 307–330, ISBN (Online): 9783110493672. DOI (Chapter): https://doi.org/10.1515/9783110493672-011.
Zhao, W., Zeng, X., Xiao, X. Thermococcus eurythermalis sp. nov., a conditional piezophilic, hyperthermophilic archaeon with a wide temperature range for growth, isolated from an oil-immersed chimney in the Guaymas Basin. (2015). International Journal of Systematic and Evolutionary Microbiology, Volumn 65 (1), pg 30-35.
Zhao, W. Xiao, X. *Complete genome sequence of Thermococcus eurythermalis A501, a conditional piezophilic hyperthermophilic archaeon with a wide temperature range, isolated from an oil-immersed deep-sea hydrothermal chimney on Guaymas Basin. Journal of Biotechnology, 193: 14-15 (2015). https://doi.org/10.1016/j.jbiotec.2014.11.006 (一作)
Wang, X., Yang, Y., Lv, Y., Xiao, X., Zhao, W., * The capability of utilizing abiotic enantiomers of amino acids by Halomonas sp. LMO_D1 derived from the Mariana Trench. Frontiers in Astronomy and Space Sciences (2021). https://doi.org/10.3389/fspas.2021.741053
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